NCT04009629 · COMPLETED
Dementia Risk and Dynamic Response to Exercise
This trial is testing how a single session of moderate aerobic exercise changes brain blood flow and blood biomarkers in older adults who carry the APOE4 gene. Researchers will measure these biological responses right after exercise to learn what exercise does in the brain of someone at higher Alzheimer's risk. This is a Phase NA study, meaning it is an observational or measurement-focused investigation, not a drug trial.
You may qualify if
- Age 65-85
- English speaking
- Normal or corrected hearing or vision,
- Without activity restrictions.
You're excluded if
- Clinically significant cognitive or psychiatric illness,
- Anti- coagulant use,
- High cardiovascular risk without physician clearance for exercise,
- Exercise-limiting musculoskeletal condition,
- MRI contraindications
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2022-05-03