NCT03876314 · COMPLETED
Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype
This trial is testing whether a structured physical activity program improves cognitive performance in middle-aged adults (40-65) who have a family history of Alzheimer's but no current cognitive impairment. Researchers are specifically examining whether APOE4 status changes how much someone benefits from exercise. It is a Phase NA behavioral trial — meaning it tests a lifestyle intervention, not a drug, and is focused on learning whether the approach works and for whom.
You may qualify if
- Family History of Alzheimer's disease, cognitive impairment
- Able to communicate in English
- Not currently meeting recommendations for physical activity (the recommendations are to exercise 3 days/week for 30+ minutes per day for longer than 3 months)
- Willing to be randomized to either study condition
- Willing to complete all study activities for 1 year
You're excluded if
- Meet the criteria for clinical cognitive impairment
- Unable to perform physical activity due to known cardiovascular, metabolic, or renal disease and are symptomatic or due to orthopedic limitations
- Self-report history of confounding neurologic, psychiatric, or active severe or functionally disabling neurologic or medical diseases, or any other conditions that might limit exercise or pose a danger to the patient
- Current use of medications to treat symptoms of Alzheimer's disease, that adversely affect cognition, or that impact heart rate
- Meet the criteria for depression using the short form of the Center for Epidemiological Studies Depression Scale
- Traveling for an extended period (>1 month) during the course of the study
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2025-04-03