NCT03676738 · COMPLETED
Cohort Study of Risk Factors for Postoperative Cognitive Decline
This observational cohort study is tracking patients who undergo elective spine surgery under general anesthesia to see who develops cognitive decline afterward — a condition called postoperative cognitive dysfunction, or POCD. Researchers want to know whether genetic factors (including possibly APOE4) and biological sex predict who is most at risk. No phase is listed because this is not a drug trial — it is a data-gathering study watching what naturally happens.
You may qualify if
- Scheduled for an in-patient, elective spine surgery where subject will receive general anesthesia
- Presenting to spine clinic and undergoing conservative, non-surgical management of spine disorder
- Subjects must have sufficient vision and hearing to complete neuropsychological testing
- Proficient in spoken and written English language
You're excluded if
- Diagnosed dementia or dementia-related treatment (i.e. donepezil prescription, or memory-care facility residence)
- Significant disease of the central nervous system (CNS) (i.e. Parkinson's disease)
- History of stroke or traumatic brain injury
- Major psychiatric disorder (i.e. schizophrenia)
- Alcohol or drug abuse according to DSM-V within the last 2 years
- Need for urgent/emergent surgery
- Surgery/anesthesia within prior 12 months
- Refusal of consent
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2022-05-26