NCT03393130 · UNKNOWN
Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's
This is an observational study, not a drug or treatment trial. Researchers are collecting DNA from people who survived a major burn injury requiring intensive care, then comparing cognitive outcomes between those who carry the APOE4 gene variant and those who do not. The idea is to explore whether APOE4 carriers suffer worse long-term cognitive impairment after the severe inflammation caused by critical illness. No phase is assigned because no treatment is being tested.
You may qualify if
- Consenting individual
- Burn injury >15% total body surface area
- Admission to a Burns Intensive Care Unit between Jan 2007- Jan 2012
- Intubated and ventilated during the admission
You're excluded if
- Patients admitted to BICU with Toxic Epidermal Necrolysis Syndrome or Steven-Johnson Syndrome
- Head trauma
- Currently held under the 2007 Mental Health Act (UK) or Section 5150 of the California Welfare and Institutions Code (USA).
- Currently receiving formal psychiatric treatment (including involvement in a Personality Disorder Unit, being under voluntary section, current re-occurrence of chronic self-harm)
- Current imprisonment
- Current substance abuse (within two weeks of assessment)
- Patients unable to understand plain verbal and written English.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2018-01-08