NCT03225144 · RECRUITING
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
This is a screening and natural history study at the NIH, not a treatment trial. Researchers are enrolling people already diagnosed with ALS, frontotemporal dementia, PSP, or related conditions caused by TDP-43 or Tau protein buildup. The goal is to evaluate whether participants qualify for future research studies and to better understand what these diseases have in common. No phase is assigned because no drug or device is being tested.
Eligibility criteria
* INCLUSION CRITERIA: Patients will be included if they * Are age 18 or older * Have been given a diagnosis by a neurologist of frontotemporal dementia, primary progressive aphasia, semantic dementia, motor neuron disorder, amyotrophic lateral sclerosis, progressive bulbar palsy, corticobasal syndrome, Huntington disease or other related adult-onset neurodegenerative disorder OR * Carry a mutation in a gene that causes familial ALS or FTD EXCLUSION CRITERIA: Patients will be excluded if they * Have other major neurological or medical diseases that may cause progressive weakness or cognitive dysfunction, such as structural brain or spinal cord disease, metabolic diseases, paraneoplastic syndromes, infectious diseases, peripheral neuropathy or radiculopathy or other significant neurological abnormalities. * Have an unstable medical condition that, in the opinion of the investigators, makes participation unsafe * Require daytime ventilator support at the time of study entry * Are unable to travel to NIH * Patients with pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments, metal fragments in the eye) will not be excluded but will not undergo magnetic resonance imaging. * Patients with tattoos above the neck or permanent make up will be excluded from undergoing 7T MRI.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2026-04-07