NCT02565511 · Phase 2 · TERMINATED
A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease
This trial tested two investigational drugs, CAD106 (a vaccine-like immunotherapy targeting amyloid) and CNP520 (a small molecule targeting amyloid production), each against placebo, in cognitively healthy older adults at high genetic risk for Alzheimer's. The goal was to see whether either drug could slow or delay the appearance of cognitive symptoms. This was a Phase 2 trial, meaning researchers were evaluating whether it worked and was safe, not a proven or approved treatment.
Eligibility criteria
Key Inclusion Criteria: * Consented to receive disclosure of their risk estimates to develop clinical symptoms of AD based on their APOE genotype. * Male or female, age 60 to 75 years inclusive. Females were to be post-menopausal. * Mini-Mental State Examination (MMSE) total score ≥ 24 and cognitively unimpaired as evaluated by memory tests * Homozygous APOE4 genotype. * Participant willing to have a study partner. Key Exclusion Criteria: * Any disability that prevented the participant from completing all study requirements. * Current medical or neurological condition that could have impacted cognition or performance on cognitive assessments. * Advanced, severe progressive or unstable disease that may have interfered with the safety, tolerability and study assessments, or put the participant at special risk. * History of malignancy of any organ system, treated or untreated, within 60 months prior to screening. * History of hypersensitivity to any of the investigational drugs or their excipients / adjuvant or to drugs of similar chemical classes. * Indication or on current treatment with ChEIs and/or another AD treatment (e.g. memantine). * Contraindication or intolerance to MRI or PET investigations (with fluorinated radio ligands). * Brain MRI results showing findings unrelated to AD that, in the opinion of the Investigator could have been a leading cause to future cognitive decline, pose a risk to the participant, or prevent a satisfactory MRI assessment for safety monitoring. * Suicidal Ideation in the past six months or Suicidal Behavior in the past two years, prior to screening. * A positive drug screen at Screening, if, in the Investigator's opinion, this was due to drug abuse. * Significantly abnormal laboratory results at Screening, or infection not as a result of a temporary condition. * Current clinically significant ECG findings. For Cohort - I only: Participants with previous organ transplantation or stem cell transplantation, or indication for treatment with anti-coagulants. For Cohort - II only: Participants with depigmenting or hypopigmenting conditions (e.g. albinism vitiligo) or active / history of chronic urticarial in the past year.
The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.
Eligibility criteria as of 2021-07-08