Genetic Characterization of Movement Disorders and Dementias

Eligibility criteria

* INCLUSION CRITERIA
For Patients:
* Diagnosis of a movement disorder or dementia by a neurologist or other qualified professional and accompanied by sufficient clinical and/or laboratory evidence to support the diagnosis
* Confirmation of a movement disorder or dementia by study investigators or a qualified clinician by physical examination and/or review of medical records
* Ages 18 and above
* Able to provide consent or, in the case of minors, or cognitive impairment, have a legally-authorized representative to provide consent
* Able to understand and participate in study procedures or for those without consent capacity, able to participate in study procedures AND has a legally authorized representative that understands the study procedures and can consent on their behalf.
For unaffected family members of patients:
* Unaffected relative of a patient diagnosed with a movement disorder or dementia enrolled in this protocol. For these purposes, we define a family member as an individual for which there is a demonstrable relationship with the proband in the pedigree. This is a standard approach used in family-based studies. Furthermore, the related patient (defined as a family member diagnosed with the disease of interest) must be enrolled in the study.
* Ages 18 and above
* Able to provide consent
* Able to understand and participate in study procedures
For unrelated healthy control individuals:
* Be in good general health
* Have no known movement disorder or dementia, or family member with a movement disorder or dementia
* Age 18 and above
* Able to provide consent
* Able to understand and participate in study procedures
EXCLUSION CRITERIA
For patients:
-An identifiable, non-genetic etiology for the movement disorder or dementia, such as a specific environmental exposure, birth injury, metabolic disorder, or brain infection such as encephalitis
For all participants:
* Clinically significant anemia that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.
* Clinically significant bleeding that would make phlebotomy unsafe, and participant unwilling to provide saliva sample.
* Any medical condition that would make phlebotomy unsafe or undesirable, such as a serious medical illness like unstable heart disease, or unstable chronic obstructive pulmonary disease, and participant unwilling to provide saliva sample.

The sponsor's own eligibility wording, lightly reformatted. The study team makes the final eligibility decision — worth discussing with your doctor.

Eligibility criteria as of 2026-03-09